{"product_id":"rho-methylfolate-5-mthf-b12","title":"RHO | Methylfolate 5-MTHF + B12","description":"\u003cp\u003e\u003cstrong\u003eMethylation, Energy, and Cellular Vitality\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eLiposomal Methylfolate + Methyl B12 Complex delivers the biologically active, methylated forms of folate (B9) and vitamin B12 in an advanced liposomal delivery system designed for enhanced absorption.*\u003c\/p\u003e\u003cp\u003eBy supporting methylation, a fundamental biochemical process involved in DNA synthesis, neurotransmitter production, and detoxification, this essential nutrient duo promotes energy metabolism, nervous system health, cardiovascular function, and overall cellular vitality.*\u003c\/p\u003e\u003cp\u003eRho uses liposomal delivery — nutrients are enclosed in tiny phosphatidylcholine-based liposomes that help protect them through digestion and support absorption.*\u003c\/p\u003e\u003ch3\u003eFAQs\u003c\/h3\u003e\u003cp\u003e\u003cstrong\u003e What is methylfolate and why is it different from regular folic acid?\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eMethylfolate (5-MTHF) is the active, bioavailable form of folate that your body can use immediately. Unlike synthetic folic acid, it does not require conversion by your body through the MTHFR enzyme. This makes it ideal for individuals who want more direct support for methylation, mood, homocysteine metabolism, cellular energy, and nervous system health.*\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWhy is methyl B12 included and how does it work with methylfolate?\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eMethyl B12 (methylcobalamin) works synergistically with methylfolate in key methylation pathways that influence neurotransmitter production, DNA synthesis, red blood cell formation, and energy metabolism.*\u003c\/p\u003e\u003cp\u003eTaking both together supports efficient methylation and balanced homocysteine levels.*\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eHow long does one bottle last?\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eEach bottle contains 30 servings. When taken daily as directed, it will last \u003cstrong\u003e30 days\u003c\/strong\u003e.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWhy liposomal? What does liposomal delivery do?\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eLiposomal delivery encapsulates nutrients inside tiny phospholipid spheres that help protect them during digestion and support efficient absorption. This system helps your body utilize more of the active forms of folate and B12 where they’re needed most - at the cellular level.*\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eIs this formula helpful for people with MTHFR variations?\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eGenetic variations such as MTHFR can reduce the body’s ability to convert folic acid and standard B12 into their active forms. Because this formula provides pre-methylated nutrients (5-MTHF + methylcobalamin), it bypasses several conversion steps and may offer more consistent support for people who need help with folate and B12 metabolism.* That said, we always recommend consulting a licensed healthcare provider for any medical questions or personal guidance.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eWhat benefits can I expect from taking this?\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eThis formula supports:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eHealthy methylation*\u003c\/li\u003e\n\u003cli\u003eCellular energy \u0026amp; metabolism*\u003c\/li\u003e\n\u003cli\u003eNervous system health \u0026amp; cognitive function*\u003c\/li\u003e\n\u003cli\u003eMood \u0026amp; emotional well-being*\u003c\/li\u003e\n\u003cli\u003eCardiovascular \u0026amp; homocysteine support*\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eBenefits vary by individual and depend on overall health, nutritional status, and consistency of use.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAre there side effects?\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eMethylated B vitamins are generally well tolerated. Occasionally, some people may feel more energized than expected or notice mild changes in sleep or mood when starting methylated forms. If you are sensitive to methyl donors, consider starting with a smaller amount and increasing as tolerated, or speak with your clinician.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003e Can I take this with my other supplements?\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eYes. All Rho products are designed to work synergistically. Methylfolate and B12 pair well with glutathione, magnesium, and other daily essentials. If you take prescription medications or have a medical condition, consult your healthcare professional before starting.\u003c\/p\u003e","brand":"RHO Nutrition","offers":[{"title":"Default Title","offer_id":52992500629786,"sku":"210000004892","price":40.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0728\/3962\/7034\/files\/180ML_Methylfolate.png?v=1791215522","url":"https:\/\/b1stshop.com\/products\/rho-methylfolate-5-mthf-b12","provider":"B1st Nutrition","version":"1.0","type":"link"}