RHO | Methylfolate 5-MTHF + B12
RHO | Methylfolate 5-MTHF + B12
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What's Inside
What's Inside
Citric acid & malic acid Clean
What it is: Acids found in citrus fruits and apples. Commercial versions are usually made by fermentation.
Why it's used: Adds tartness and keeps products fresh.
Our take: Clean. Usually used in small amounts.
See every B1st product with this →Methylated B vitamins (methylfolate, methylcobalamin) Clean
What it is: Active forms of folate and vitamin B12.
Why it's used: Used as the B-vitamin source in supplements.
Our take: Clean. A go-to for us.
See every B1st product with this →Monk fruit extract Clean
What it is: A zero-calorie sweetener extracted from monk fruit, a small melon.
Why it's used: Adds sweetness without sugar, often alongside stevia or allulose.
Our take: Clean. A go-to for us.
See every B1st product with this →Preservatives (sodium benzoate, potassium sorbate) Okay
What it is: Common preservatives.
Why it's used: Keep drinks and foods shelf-stable.
Our take: Okay. We like it when a product doesn’t need them.
Why it's flagged: FDA has noted that sodium benzoate and vitamin C together can form trace amounts of benzene in some drinks, especially with heat or light. FDA’s testing found most beverages at very low levels. Source
See every B1st product with this →Sunflower lecithin Clean
What it is: An emulsifier made from sunflower seeds.
Why it's used: Helps powders mix and keeps ingredients blended.
Our take: Clean. Soy-free.
See every B1st product with this →Tiers apply to food, drinks and supplements. Ingredient glossary →
Description
Description
Methylation, Energy, and Cellular Vitality
Liposomal Methylfolate + Methyl B12 Complex delivers the biologically active, methylated forms of folate (B9) and vitamin B12 in an advanced liposomal delivery system designed for enhanced absorption.*
By supporting methylation, a fundamental biochemical process involved in DNA synthesis, neurotransmitter production, and detoxification, this essential nutrient duo promotes energy metabolism, nervous system health, cardiovascular function, and overall cellular vitality.*
Rho uses liposomal delivery — nutrients are enclosed in tiny phosphatidylcholine-based liposomes that help protect them through digestion and support absorption.*
FAQs
What is methylfolate and why is it different from regular folic acid?
Methylfolate (5-MTHF) is the active, bioavailable form of folate that your body can use immediately. Unlike synthetic folic acid, it does not require conversion by your body through the MTHFR enzyme. This makes it ideal for individuals who want more direct support for methylation, mood, homocysteine metabolism, cellular energy, and nervous system health.*
Why is methyl B12 included and how does it work with methylfolate?
Methyl B12 (methylcobalamin) works synergistically with methylfolate in key methylation pathways that influence neurotransmitter production, DNA synthesis, red blood cell formation, and energy metabolism.*
Taking both together supports efficient methylation and balanced homocysteine levels.*
How long does one bottle last?
Each bottle contains 30 servings. When taken daily as directed, it will last 30 days.
Why liposomal? What does liposomal delivery do?
Liposomal delivery encapsulates nutrients inside tiny phospholipid spheres that help protect them during digestion and support efficient absorption. This system helps your body utilize more of the active forms of folate and B12 where they’re needed most - at the cellular level.*
Is this formula helpful for people with MTHFR variations?
Genetic variations such as MTHFR can reduce the body’s ability to convert folic acid and standard B12 into their active forms. Because this formula provides pre-methylated nutrients (5-MTHF + methylcobalamin), it bypasses several conversion steps and may offer more consistent support for people who need help with folate and B12 metabolism.* That said, we always recommend consulting a licensed healthcare provider for any medical questions or personal guidance.
What benefits can I expect from taking this?
This formula supports:
- Healthy methylation*
- Cellular energy & metabolism*
- Nervous system health & cognitive function*
- Mood & emotional well-being*
- Cardiovascular & homocysteine support*
Benefits vary by individual and depend on overall health, nutritional status, and consistency of use.
Are there side effects?
Methylated B vitamins are generally well tolerated. Occasionally, some people may feel more energized than expected or notice mild changes in sleep or mood when starting methylated forms. If you are sensitive to methyl donors, consider starting with a smaller amount and increasing as tolerated, or speak with your clinician.
Can I take this with my other supplements?
Yes. All Rho products are designed to work synergistically. Methylfolate and B12 pair well with glutathione, magnesium, and other daily essentials. If you take prescription medications or have a medical condition, consult your healthcare professional before starting.
Ingredients
Ingredients
Serving size: 6 mL (just over one teaspoon)
Servings per bottle: 30
Folate (as L-Methyltetrahydrofolate)...5 mg DFE (1,250% DV)
B12 (as Methylcobalamin)...1,000 mcg (41,667% DV)
* %DV (Daily Value) not established
Other Ingredients: Purified Water, Glycerin, Monk Fruit Juice (Siraitia grosvenorii), Natural Orange, Pineapple, and Tropical Fruit Flavors, Non-GMO Sunflower Lecithin, Citric Acid, Potassium Sorbate
Always refer to the product label for the most current ingredient information.
Benefits
Benefits
- Supports cellular energy and metabolism*
- Promotes healthy nervous system function*
- Active folate and B12 for methylation support*
- Supports healthy homocysteine metabolism*
Methylation & Homocysteine Support
Supports healthy methylation processes throughout the body, including DNA synthesis, neurotransmitter production, and detoxification pathways.*
Cardiovascular Health
Supports cardiovascular function through healthy homocysteine metabolism and maintenance of healthy blood vessels. Essential for heart health and circulation.*
Energy Production & Metabolism
Both folate and B12 play critical roles in cellular energy production and the metabolism of fats, proteins, and carbohydrates. Supports sustained energy and metabolic efficiency throughout the day.*
Nervous System & Cognitive Function
Supports healthy nervous system structure and function, promotes cognitive performance, mental clarity, and healthy neurotransmitter synthesis including serotonin, dopamine, and norepinephrine.*
Mood & Mental Well-Being
Supports healthy mood and emotional balance through neurotransmitter synthesis and methylation pathways. Research shows methylfolate and methyl B12 may support mental wellness when used as part of a comprehensive approach.*
Features
Features
- Liposomal delivery for absorption support
- Third-party tested
- Refrigeration optional — Rho suggests refrigerating for the best taste
Directions & Warnings
Directions & Warnings
Directions:
How do I take Liposomal Methylfolate + B12?
Take 6 mL (just over one teaspoon) per day, or as recommended by your healthcare practitioner. You can take it directly from the spoon or mix it into cold water or juice.
Does it need to be refrigerated?
Before opening:Store in a cool, dry place.
After opening: While its not required, some people like to refrigerate for taste and freshness.
Use within 75 days of opening.
Warnings: Keep out of reach of children. If you are pregnant, nursing, taking any medications, or have a medical condition, consult your healthcare provider before use.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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