RHO | TMG

Methylation, Homocysteine, Sport, & Liver Support

Liposomal TMG delivers trimethylglycine (TMG), also known as betaine, a naturally occurring nutrient found in foods like beets and spinach. TMG supports healthy homocysteine metabolism and methylation pathways involved in energy production, detoxification, and overall metabolic balance. It also supports normal liver fat metabolism and may help support performance, recovery, and body composition when paired with a healthy lifestyle and regular movement.*

Supports exercise performance, recovery, and body composition when combined with training*

Rho uses liposomal delivery — nutrients are enclosed in tiny phosphatidylcholine-based liposomes that help protect them through digestion and support absorption.*

FAQs

What is TMG and how does it work?

TMG (trimethylglycine), also known as betaine, is a naturally occurring compound found in foods such as beets, spinach, and whole grains. In the body, it acts as a methyl donor that helps recycle homocysteine back to methionine, supporting SAMe production and overall methylation activity.* TMG also functions as a cellular osmolyte, helping cells maintain normal fluid balance and resilience under metabolic and environmental stress.*

How is Liposomal TMG different from regular TMG supplements?

Liposomal TMG+ encapsulates TMG inside tiny phospholipid spheres that resemble cell membranes.* This delivery system is designed to help protect TMG through the digestive tract and support efficient absorption and cellular uptake, so more of what you take is available for use by your cells compared to standard non-liposomal forms.*

Who might benefit from Liposomal TMG?

Liposomal TMG+ is designed for adults looking to support healthy homocysteine metabolism, methylation pathways, and liver function.* It can also be a useful addition for individuals focused on performance, recovery, and maintaining a healthy body composition, especially when combined with a nutrient-dense diet, regular exercise, and other foundational lifestyle habits.*

Does TMG support heart health?

TMG helps support healthy homocysteine metabolism, and homocysteine is one factor involved in cardiovascular health.*

While TMG is not intended to diagnose, treat, cure, or prevent cardiovascular disease, supporting normal homocysteine metabolism is one way to help maintain overall cardiovascular function as part of a comprehensive lifestyle approach.*

Can I take Liposomal TMG with medications or other supplements?

If you take prescription medications or have a medical condition, including cardiovascular, liver, or kidney conditions, talk with your healthcare provider before using Liposomal TMG+.* TMG is often used alongside B vitamins, creatine, and other metabolic support nutrients, but your clinician can help you determine the best combination for your individual needs.*

Are there side effects?

TMG is generally well tolerated. Some individuals may notice mild digestive changes when starting TMG-containing supplements, especially at higher intakes.* If you are sensitive, consider starting with a smaller amount and gradually increasing to the full serving as tolerated. As always, speak with your clinician if you have specific concerns or if you experience persistent discomfort.*

Is Liposomal TMG+ allergen-friendly and tested for quality?

Yes. All Rho products are manufactured in a non-GMO, gluten-free, soy-free, dairy-free, and nut-free facility. Every batch undergoes third-party testing for identity, purity, potency, and contaminants. All Rho products are produced in a cGMP-certified, FDA-registered facility with full quality documentation.